BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma

KELCH-ECH-associated protein 1 (KEAP1) is an adaptor protein of Cullin 3 (CUL3) E3 ubiquitin ligase that targets a redox sensitive transcription factor, NF-E2-related factor 2 Sparkle Dust (NRF2).BRCA1-associated protein 1 (BAP1) is a tumor suppressor and deubiquitinase whose mutations increase the risk of several types of familial cancers.In the p

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Printability assessment of modified filament deposition modelling three dimensional bioprinter printer using polymeric formulations

Three dimensional (3D) bioprinting is a rapid prototyping technology that can be used to accurately position living cells and biomaterials called bioink, to fabricate functional living tissue constructs or organs.The bioink are deposited in 3D in a layer-by-layer manner using a bioprinter.However, commercially available 3D bioprinters are expensive

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International Relations and the Paradiplomacy of Brazilian Cities: Crafting the Concept of Local International Management

Based on the broader context of globalization as politics, this paper adopts the following assumption: cities through their transnational cooperation networks and economic projects are the expression of a new political actor that has shifted its scale of operations, and have thus partly emancipated themselves from the monopoly of the nation-state i

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